Hôpital Saint-Louis AP-HP – Projet Lymphome T

Current mission

It is clear that the immune profile of the tumor in numerous solid tumors strongly influences their prognosis. The development of immunotherapies represents a clear revolution in patient care. In this context, the analysis of the spatial tumor-immune microenvironments (TIME), is of major interest for the knowledge of cancer and the discovery of new innovative therapies. T-cell lymphomas constitute a broad spectrum of hemopathies for which conventional therapies have limited effectiveness. To date, TIME in T-cell lymphomas remains poorly defined. We propose to uncovering it, taking advantage of state-of-the-art tools in spatial analysis such as multiplex immunofluorescence and CO-Detection by indEXing (CODEX) (simultaneous detection of 5-50 proteins) and spatial transcriptomics (simultaneous detection of several thousand transcripts). Mapping the TIME in T-cell lymphomas will lead to identifying rational tumor subtypes and immunological targets for innovative therapeutic strategies.

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  https://hopital-saintlouis.aphp.fr/

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